The state of Massachusetts currently has 16 active clinical trials seeking participants for Osteoarthritis research studies. These trials are conducted in various cities, including Boston, Worcester, Springfield and Burlington.
Actis Total Hip System 2 Year Follow-up
Recruiting
Two-year (2 year) information regarding the performance of the commercially available Actis™ Total Hip System in order to obtain and evaluate the clinical outcomes on a series of cementless primary total hip arthroplasty (THA) and hemi-hip arthroplasty procedures using clinical, radiographic and device and procedure related adverse event assessments.
Gender:
All
Ages:
21 years and above
Trial Updated:
06/18/2024
Locations: Not set, Boston, Massachusetts
Conditions: Osteoarthritis, Traumatic Arthritis, Rheumatoid Arthritis, Congenital Hip Dysplasia, Avascular Necrosis of the Femoral Head, Acute Traumatic Fracture of the Femoral Head or Neck, Certain Cases of Ankylosis, Non-union of Femoral Neck Fractures, Certain High Sub-Capital & Femoral Neck Fractures in Elderly
A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight
Recruiting
The purpose of this study is to evaluate the efficacy and safety of retatrutide in participants who have obesity or overweight (J1I-MC-GZBJ master protocol) including subsets of participants who have knee osteoarthritis (OA) (J1I-MC-GOA1) or who have obstructive sleep apnea (OSA) (J1I-MC-GSA1). This study will last about 89 weeks and will include up to 24 visits.
Gender:
All
Ages:
18 years and above
Trial Updated:
06/17/2024
Locations: MedVadis Research Corporation, Waltham, Massachusetts
Conditions: Obesity, Overweight, Knee Pain Chronic, Knee Osteoarthritis, Obstructive Sleep Apnea
Study of Efficacy, Safety and Tolerability of DFV890 in Patients With Knee Osteoarthritis
Recruiting
This is a double-blinded, two-arm, phase II study to assess efficacy, safety and tolerability of DFV890 in participants with symptomatic knee osteoarthritis. The study includes a screening period, a treatment period and a follow-up period. At most, the study duration is 21 weeks.
Gender:
All
Ages:
Between 50 years and 80 years
Trial Updated:
06/03/2024
Locations: Boston Univ School Of Medicine ., Boston, Massachusetts
Conditions: Symptomatic Knee Osteoarthritis
The Osteoarthritis Prevention Study
Recruiting
The goal of this study is to establish the efficacy of an intervention of dietary weight loss, exercise, and weight-loss maintenance for knee Osteoarthritis (OA) prevention in adult females aged ≥ 50 years with obesity and no or infrequent knee pain. The primary aim is to compare the effects of a dietary weight loss, exercise, and weight-loss maintenance to an attention control group in preventing the development of structural Magnetic Resonance Imaging (MRI) knee OA. Secondary aims will determi... Read More
Gender:
Female
Ages:
50 years and above
Trial Updated:
05/31/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Osteoarthritis, Knee
A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain
Recruiting
The purpose of the chronic pain master protocol is to compare independent pain interventions and establish an overarching structure for the disease-state addenda (DSA) and intervention-specific appendices (ISAs). The ISAs may start independently of other ISAs as interventions become available for clinical testing.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/24/2024
Locations: ActivMed Practices and Research, Methuen, Massachusetts +1 locations
Conditions: Osteoarthritis, Knee, Diabetic Neuropathic Pain, Chronic Low-back Pain
Preventing Injured Knees From osteoArthritis: Severity Outcomes
Recruiting
This study is being done to find out if metformin is effective at reducing pain by delaying the onset of post-traumatic osteoarthritis (PTOA) after anterior cruciate ligament (ACL) reconstruction. This research study will compare metformin to placebo. The placebo tablet looks exactly like metformin, but contains no metformin. Placebos are used in research studies to see if the results are due to the study drug or due to other reasons. Metformin is approved by the U.S. Food and Drug Administrati... Read More
Gender:
All
Ages:
Between 18 years and 45 years
Trial Updated:
05/07/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Osteoarthritis, Knee, Post-traumatic Osteoarthritis, ACL Tear
Strengthening of the First Dorsal Interosseous for Thumb Carpometacarpal Osteoarthritis
Recruiting
To determine the effect of first dorsal interosseus (FDI) strengthening in patients with thumb carpometacarpal (CMC) osteoarthritis.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/30/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Thumb Osteoarthritis, First Dorsal Interosseous Strengthening
Enhancing Modulation Effects of Baduanjin Through Neuromodulation for Knee OA
Recruiting
This study will combine brain imaging and neuromodulation tools to investigate the underlying neurobiological mechanisms of exercises. The findings will enhance our understanding of the mechanisms underlying mind-body exercise and facilitate the development of new pain management approaches.
Gender:
All
Ages:
Between 45 years and 75 years
Trial Updated:
04/24/2024
Locations: Massachusetts General Hospital, Charlestown, Massachusetts
Conditions: Knee Osteoarthritis
Knee Arthroplasty Activity Trial
Recruiting
Total knee replacement (TKR) is a common and costly procedure widely used to relieve pain and improve function in patients with symptomatic advanced knee osteoarthritis (OA). As of 2013, the annual incidence of TKR was over 680,000 surgeries and annual costs exceeded $11 billion. Growing evidence suggests that while pain and functional status improve following TKR, physical activity (PA) typically does not surpass pre-TKR levels. Engagement in PA can meaningfully improve quality of life (QoL), p... Read More
Gender:
All
Ages:
Between 40 years and 85 years
Trial Updated:
04/15/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Knee Osteoarthritis, Total Knee Replacement
A Sequenced Strategy for Improving Outcomes in People With Knee Osteoarthritis Pain
Recruiting
There is an urgent public health need to reduce reliance on opioids for effective long-term pain management, particularly in knee osteoarthritis (KOA). This effectiveness trial will compare commonly recommended treatments to reduce pain and functional limitations in KOA.These results will lead to improved patient selection for treatment and inform evidence based guidelines by offering well-tested, effective, non-surgical alternatives.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/07/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Knee Osteoarthritis
A Study to Evaluate the Efficacy of Amniotic Suspension Allograft in Patients With Osteoarthritis of the Knee
Recruiting
This study is being conducted to evaluate the efficacy and safety of ASA compared to placebo in the management of osteoarthritis (OA) symptoms of the knee.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/01/2024
Locations: Skylight Health Research, Burlington, Massachusetts
Conditions: Knee Osteoarthritis
Total Joint Arthroplasty (TJA) Weight Loss Study
Recruiting
This is a randomized clinical trial (RCT) to assess the efficacy of bariatric surgery vs medical weight loss vs. the "usual standard of care" to optimize a morbidly obese patient with end-stage osteoarthritis of the hip or knee joint for total joint arthroplasty (TJA). The study population will include patients with hip or knee joint osteoarthritis and BMI (Body Mass Index) > 40 kg/m2 who are evaluated in the joint arthroplasty clinic at Boston Medical Center. The primary objective of the stud... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/09/2023
Locations: Boston Medical Center, Boston, Massachusetts
Conditions: Osteoarthritis, Hip, Osteoarthritis, Knee, Obesity, Morbid